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Commit 9dc9a573 authored by Elin Nyman's avatar Elin Nyman
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Matlab files to reproduce the results of the manuscript **Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling** by Nyman et al.
The IQM toolbox is used.
First, you need to install the toolbox from https://iqmtools.intiquan.com/
Second, run the file `initIQM.m`
To reproduce the results in the manuscript, run `plot_many_params.m` for each hypothesis
The included files:
`Macrophage_simple.txt` model text file used for hypothesis testing in the format of the IQM toolbox
`Macrophage_treatment.txt` model text file for the model used to simulate treatment scenarios in in the format of the IQM toolbox
`allGoodValuesX.dat` contains acceptable parameter values
`cost_simple.m` computes the cost and need a set of parameter values as input
`Optimization_simple.m` main script to use in the optimization of parameters
`LoadData.m` computes mean values and standard error of the means from the raw data with only LPS stimulation and load to workspace
`LoadDrugData.m` computes mean values and standard error of the means from the raw data with addition of Dexamathasone and load to workspace
`plot_many_params.m` simulate the model and plot for all loaded acceptable parameter values
`plot_treatment.m` simulate the treatment model and plot for for all loaded acceptable parameter values
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