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README.md 933 B

Matlab files to reproduce the results of the manuscript Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling by Nyman et al.

The IQM toolbox is used.

First, you need to install the toolbox from https://iqmtools.intiquan.com/

Second, run the file initIQM.m

To reproduce the results in the manuscript, run plot_many_params.m for each hypothesis

The included files:

macrophage_simple.txt model text file in the format of the IQM toolbox

allGoodValuesX.dat contains acceptable parameter values

cost_simple.m computes the cost and need a set of parameter values as input

LoadData.m computes mean values and standard error of the means from the raw data with only LPS stimulation and load to workspace

LoadDrugData.m computes mean values and standard error of the means from the raw data with addition of Dexamathasone and load to workspace

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