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Commit 0dc8036b authored by Tilda Herrgårdh's avatar Tilda Herrgårdh
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# Weight-Driven IR # Weight-Driven IR
These are the scripts used in the publication "A multi-scale digital twin for adiposity-driven insulin resistance in humans: diet and drug effects" DOI: 10.1186/s13098-023-01223-6 These are the scripts used in the publication "A multi-scale digital twin for adiposity-driven insulin resistance in humans: diet and drug effects" [DOI: 10.1186/s13098-023-01223-6](10.1186/s13098-023-01223-6)
The models are simulated using the toolbox [IQM tools](https://iqmtools.intiquan.com/), which requires a working C-compiler. The toolbox is included in this repo. The models are simulated using the toolbox [IQM tools](https://iqmtools.intiquan.com/), which requires a working C-compiler. The toolbox is included in this repo.
To generate all the figures presented in the paper, run plotAllFigures. To generate all the figures presented in the paper, run plotAllFigures.
The code used to estimate parameters are found in scripts The code used to estimate parameters are found in scripts
- mainOptFastfood for estimation to the Fast food data, mainOptTop for the topiramate data, and mainOptMeal for the glucose meal dynamics data. \- mainOptFastfood for estimation to the Fast food data, mainOptTop for the topiramate data, and mainOptMeal for the glucose meal dynamics data.
To rerun the estimations, [MEIGO64 toolbox](https://github.com/gingproc-IIM-CSIC/MEIGO64) is required, which is not included in this repo. To rerun the estimations, [MEIGO64 toolbox](https://github.com/gingproc-IIM-CSIC/MEIGO64) is required, which is not included in this repo.
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