diff --git a/Core/src/org/sleuthkit/autopsy/corecomponents/Bundle.properties-MERGED b/Core/src/org/sleuthkit/autopsy/corecomponents/Bundle.properties-MERGED
index c6f78680ca5e0e289d02569e66a181c4383a9d3c..6a7e8b004ff51e3cab1ffa777793da8ccc8dc190 100755
--- a/Core/src/org/sleuthkit/autopsy/corecomponents/Bundle.properties-MERGED
+++ b/Core/src/org/sleuthkit/autopsy/corecomponents/Bundle.properties-MERGED
@@ -52,6 +52,7 @@ DataResultViewerThumbnail.sortLabel.textTemplate=Sorted by: {0}
 DataResultViewerThumbnail.thumbnailSizeComboBox.large=Large Thumbnails
 DataResultViewerThumbnail.thumbnailSizeComboBox.medium=Medium Thumbnails
 DataResultViewerThumbnail.thumbnailSizeComboBox.small=Small Thumbnails
+MultiUserSettingsPanel_Close_Case_To_Modify=Close case to modfy settings
 OptionsCategory_Name_General=Application
 OptionsCategory_Keywords_General=Autopsy Options
 HINT_DataContentTopComponent=This is a DataContent window
diff --git a/Core/src/org/sleuthkit/autopsy/corecomponents/MultiUserSettingsPanel.java b/Core/src/org/sleuthkit/autopsy/corecomponents/MultiUserSettingsPanel.java
index 65c447c7afd4a186278a12e38ad50eef652b49ff..2556674e01cd3b56ddff2017f445a830afaa3182 100644
--- a/Core/src/org/sleuthkit/autopsy/corecomponents/MultiUserSettingsPanel.java
+++ b/Core/src/org/sleuthkit/autopsy/corecomponents/MultiUserSettingsPanel.java
@@ -32,13 +32,17 @@
 import org.sleuthkit.autopsy.events.MessageServiceConnectionInfo;
 import org.sleuthkit.autopsy.coreutils.Logger;
 import java.awt.Cursor;
+import java.beans.PropertyChangeEvent;
 import java.io.IOException;
+import java.util.EnumSet;
 import java.util.logging.Level;
 import javax.swing.ImageIcon;
 import javax.swing.JOptionPane;
 import javax.swing.SwingUtilities;
 import org.openide.util.ImageUtilities;
 import org.openide.util.Lookup;
+import org.openide.util.NbBundle.Messages;
+import org.sleuthkit.autopsy.casemodule.Case;
 import org.sleuthkit.autopsy.coordinationservice.utils.CoordinationServiceUtils;
 import org.sleuthkit.autopsy.core.UserPreferencesException;
 import org.sleuthkit.autopsy.coreutils.PlatformUtil;
@@ -159,6 +163,11 @@ public MultiUserSettingsPanel(MultiUserSettingsPanelController theController) {
         goodIcon = new ImageIcon(ImageUtilities.loadImage("org/sleuthkit/autopsy/images/good.png", false));
         badIcon = new ImageIcon(ImageUtilities.loadImage("org/sleuthkit/autopsy/images/bad.png", false));
         enableMultiUserComponents(textBoxes, cbEnableMultiUser.isSelected());
+        
+        Case.addEventTypeSubscriber(EnumSet.of(Case.Events.CURRENT_CASE), (PropertyChangeEvent evt) -> {
+            //disable when case is open, enable when case is closed
+            load(evt.getNewValue() != null);
+        });
     }
 
     /**
@@ -806,7 +815,11 @@ private void bnTestZKActionPerformed(java.awt.event.ActionEvent evt) {//GEN-FIRS
         }
     }//GEN-LAST:event_bnTestZKActionPerformed
 
-    void load() {
+    @Messages({
+       "MultiUserSettingsPanel_Close_Case_To_Modify=Close case to modfy settings" 
+    })
+    
+    void load(boolean caseOpen) {
         lbTestDatabase.setIcon(null);
         lbTestSolr8.setIcon(null);
         lbTestSolr4.setIcon(null);
@@ -845,7 +858,13 @@ void load() {
         bnTestMessageService.setEnabled(false);
 
         cbEnableMultiUser.setSelected(UserPreferences.getIsMultiUserModeEnabled());
-        this.valid(); // trigger validation to enable buttons based on current settings
+        
+        // When a case is open, prevent the user from changing
+        // multi-user settings.
+        cbEnableMultiUser.setEnabled(!caseOpen);
+        enableMultiUserComponents(textBoxes, cbEnableMultiUser.isSelected() && !caseOpen);
+               
+        this.valid(caseOpen); // trigger validation to enable buttons based on current settings
     }
 
     private void populateSolrAndZkSettings() {
@@ -1096,11 +1115,15 @@ && arePropsEqual(a.getPort(), b.getPort())
      *
      * @return true if it's okay, false otherwise.
      */
-    boolean valid() {
-        tbOops.setText("");
-
+    boolean valid(boolean caseOpen) {
+        if(caseOpen) {
+            tbOops.setText(Bundle.MultiUserSettingsPanel_Close_Case_To_Modify());
+        } else {
+            tbOops.setText("");
+        }
+        
         if (cbEnableMultiUser.isSelected()) {
-            return checkFieldsAndEnableButtons()
+            return checkFieldsAndEnableButtons(caseOpen)
                     && databaseSettingsAreValid()
                     && indexingServerSettingsAreValid()
                     && messageServiceSettingsAreValid();
@@ -1115,7 +1138,7 @@ && indexingServerSettingsAreValid()
      *
      * @return True or false.
      */
-    boolean checkFieldsAndEnableButtons() {
+    boolean checkFieldsAndEnableButtons(boolean caseOpen) {
         boolean result = true;
 
         boolean dbPopulated = databaseFieldsArePopulated();
@@ -1125,15 +1148,15 @@ boolean checkFieldsAndEnableButtons() {
         boolean messageServicePopulated = messageServiceFieldsArePopulated();
 
         // PostgreSQL Database
-        bnTestDatabase.setEnabled(dbPopulated);
+        bnTestDatabase.setEnabled(dbPopulated && !caseOpen);
 
         // Solr Indexing
-        bnTestSolr8.setEnabled(solr8Populated);
-        bnTestSolr4.setEnabled(solr4Populated);
-        bnTestZK.setEnabled(zkPopulated);
+        bnTestSolr8.setEnabled(solr8Populated && !caseOpen);
+        bnTestSolr4.setEnabled(solr4Populated && !caseOpen);
+        bnTestZK.setEnabled(zkPopulated && !caseOpen);
 
         // ActiveMQ Messaging
-        bnTestMessageService.setEnabled(messageServicePopulated);
+        bnTestMessageService.setEnabled(messageServicePopulated && !caseOpen);
 
         if (dbPopulated && messageServicePopulated && zkPopulated && (solr8Populated || solr4Populated)) {
             result = true;
diff --git a/Core/src/org/sleuthkit/autopsy/corecomponents/MultiUserSettingsPanelController.java b/Core/src/org/sleuthkit/autopsy/corecomponents/MultiUserSettingsPanelController.java
index 212bfa7dcdafbe2230eb68dd3e8857792fde7b9e..536018955ed90062a70cbae5afa18e3b9ce25f11 100644
--- a/Core/src/org/sleuthkit/autopsy/corecomponents/MultiUserSettingsPanelController.java
+++ b/Core/src/org/sleuthkit/autopsy/corecomponents/MultiUserSettingsPanelController.java
@@ -27,6 +27,7 @@
 import org.openide.util.NbBundle;
 import org.sleuthkit.autopsy.coreutils.MessageNotifyUtil;
 import java.util.logging.Level;
+import org.sleuthkit.autopsy.casemodule.Case;
 import org.sleuthkit.autopsy.coreutils.Logger;
 
 @OptionsPanelController.TopLevelRegistration(categoryName = "#OptionsCategory_Name_Multi_User_Settings",
@@ -43,7 +44,7 @@ public final class MultiUserSettingsPanelController extends OptionsPanelControll
 
     @Override
     public void update() {
-        getPanel().load();
+        getPanel().load(Case.isCaseOpen());
         changed = false;
     }
 
@@ -59,7 +60,7 @@ public void cancel() {
 
     @Override
     public boolean isValid() {
-        return getPanel().valid();
+        return getPanel().valid(Case.isCaseOpen());
     }
 
     @Override
diff --git a/docs/doxygen-user/images/activeMQ_node_cleanup.png b/docs/doxygen-user/images/activeMQ_node_cleanup.png
new file mode 100644
index 0000000000000000000000000000000000000000..739d6e6ad75ade25128fffb4101360abd44297eb
Binary files /dev/null and b/docs/doxygen-user/images/activeMQ_node_cleanup.png differ
diff --git a/docs/doxygen-user/multi-user/installActiveMQ.dox b/docs/doxygen-user/multi-user/installActiveMQ.dox
index 07a6f1dcfdc9d2319977692f9e7cbc96eb5c81f5..5cedc7b348e8e4897f046350a67fad8fd9bd8f3e 100644
--- a/docs/doxygen-user/multi-user/installActiveMQ.dox
+++ b/docs/doxygen-user/multi-user/installActiveMQ.dox
@@ -24,20 +24,27 @@ If you need the JRE, install it with the default settings.
 
 \subsection install_activemq_install_mq ActiveMQ Installation
 
-1. Extract the contents of the ActiveMQ archive folder to a location of your choice, bearing in mind that the files should be in a location that the running process will have write permissions to the folder. A typical folder choice would be similar to <i>C:\\Program Files\\apache-activemq-5.13.3</i>. Typically, it will ask for administrator permission to move the folder. Allow it if required. 
+<ol>
+<li>Extract the contents of the ActiveMQ archive to a location of your choice, bearing in mind that the files should be in a location where the running process has write permissions. A typical folder choice would be similar to <i>C:\\Program Files\\apache-activemq-5.13.3</i>. The system may ask for administrator permission to move the folder. Allow it if required. 
 
-2. Edit the <i>conf\\activemq.xml</i> in the extracted folder to add <i>"&amp;wireFormat.maxInactivityDuration=0"</i> to the URI for the _transportConnector_ named _openwire_. Add the text highlighted in yellow below:
+<li>Open the <i>conf\\activemq.xml</i> file in the extracted folder in a text editor and make the following changes:
+<ul>
+<li> Add <i>"schedulePeriodForDestinationPurge="10000""</i> to the _broker_ tag then add <i>"gcInactiveDestinations="true" inactiveTimoutBeforeGC="30000""</i> to the _policyEntry_ tag. This is highlighted in yellow below:
+
+\image html activeMQ_node_cleanup.png
+
+<li>Add <i>"&amp;wireFormat.maxInactivityDuration=0"</i> to the URI for the _transportConnector_ named _openwire_. This is highlighted in yellow below:
 <br><br>
 \image html maxinactivityduration.PNG
 <br><br>
+</ul>
 
+<li>Install ActiveMQ as a service by navigating to the folder <i>bin\\win64</i>, right-clicking _InstallService.bat_, clicking _Run as administrator_, then click _Yes_.
 
-3. Install ActiveMQ as a service by navigating to the folder <i>bin\\win64</i>, right-clicking _InstallService.bat_, clicking _Run as administrator_, then click _Yes_.
-
-4. Start the ActiveMQ service by pressing _Start_, type _services.msc_, and press _Enter_. Find _ActiveMQ_ in the list and press the _Start the service_ link.
-
-5. ActiveMQ should now be installed and configured using the default credentials. 
+<li>Start the ActiveMQ service by pressing _Start_, type _services.msc_, and press _Enter_. Find _ActiveMQ_ in the list and press the _Start the service_ link.
 
+<li>ActiveMQ should now be installed and configured using the default credentials. 
+</ol>
 
 \subsection install_activemq_test Testing