diff --git a/scripts/Models/M1.txt b/scripts/Models/M1.txt index 84cf631d421b3478ed67aa963f97b68ec99afabc..5236f8094be2b1cac7ea59634a028698a5f013d7 100644 --- a/scripts/Models/M1.txt +++ b/scripts/Models/M1.txt @@ -31,12 +31,11 @@ d/dt(GLUT4) = -v7f+v7b %%24 d/dt(S6K) = v9b1-v9f1 %%26 d/dt(S6Kp) = v9f1-v9b1 %%27 d/dt(S6) = v9b2-v9f2 %%28 -d/dt(S6p) = v9f2-v9b2 %%29 - +d/dt(S6p) = v9f2-v9b2 %%29 d/dt(G_p) = EGP+Ra-E-U_ii-k_1*G_p+k_2*G_t -d/dt(G_t) = (-U_id)+k_1*G_p-k_2*G_t -d/dt(I_p) = (-m_2*I_p)-m_4*I_p+m_1*I_l +d/dt(G_t) = (-U_id)+k_1*G_p-k_2*G_t d/dt(I_l) = (-m_1*I_l)-m_3*I_l+m_2*I_p+S +d/dt(I_p) = (-m_2*I_p)-m_4*I_p+m_1*I_l d/dt(Q_sto1) = -k_gri*Q_sto1 d/dt(Q_sto2) = (-k_empt*Q_sto2)+k_gri*Q_sto1 d/dt(Q_gut) = (-k_abs*Q_gut)+k_empt*Q_sto2 @@ -74,8 +73,7 @@ GLUT4(0) = 100 S6K(0) = 100 S6Kp(0) = 0 S6(0) = 100 -S6p(0) = 0 - +S6p(0) = 0 G_p(0) = 178 G_t(0) = 130 I_l(0) = 4.5 @@ -137,7 +135,7 @@ k9b2 = 30.9967 %%42 km9 = 5872.68 %%43 n9 = 0.985466 %%44 kbf = 1e+06 %%45 -nC = 2.1e-06 %%46 +scaleModel = 2.1e-06 %%46 V_G = 1.88 %%47 k_1 = 0.065 %%48 @@ -166,38 +164,33 @@ k_p3 = 0.009 %%70 k_p4 = 0.0618 %%71 k_i = 0.0079 %%72 -V_m0 = 2.5 %%73 -V_mX = 0.047 %%74 -K_m0 = 225.59 %%75 -V_f0 = 2.5 %%76 -V_fX = 0.047 %%77 -K_f0 = 225.59 %%78 -p_2U = 0.0331 %%79 -part = 0.2 %%80 -K = 2.3 %%81 -alpha = 0.05 %%82 -beta = 0.11 %%83 -gamma = 0.5 %%84 -k_e1 = 0.0005 %%85 -k_e2 = 339 %%86 -D = 78000 %%87 +V_m0 = 2.5 %%74 +V_mX = 0.047 %%75 +K_m0 = 225.59 %%76 +V_f0 = 2.5 %%77 +V_fX = 0.047 %%78 +K_f0 = 225.59 %%79 +p_2U = 0.0331 %%80 +part = 0.2 %%81 +K = 2.3 %%82 +alpha = 0.05 %%83 +beta = 0.11 %%84 +gamma = 0.5 %%85 +k_e1 = 0.0005 %%86 +k_e2 = 339 %%87 +D = 78000 %%88 -K_l0 = 225.59 %%88 -V_l0 = 2.5 %%89 -V_lX = 0.047 %%90 -pf = 34 - -U_ii = 0.8 -part_m = 0.5 -part_f = 0.5 -part_l = 1.7 +K_l0 = 225.59 +V_l0 = 2.5 +V_lX = 0.047 ********** MODEL VARIABLES aa = 5/2/(1-b)/D cc = 5/2/d/D EGP = k_p1-k_p2*G_p-k_p3*I_d-k_p4*I_po V_mmax = (1-part)*(V_m0+V_mX*INS) -V_fmax = part*(V_f0+V_fX*INS) +V_fmax = part*(V_f0+V_fX*INS) +V_lmax = (1-part)*(V_l0+V_lX*G_t) Ee = k_e1*(G_p - k_e2) S = gamma*I_po I = I_p/V_I @@ -207,11 +200,13 @@ m_3 = HE*m_1/(1-HE) Q_sto = Q_sto1+Q_sto2 Ra = f*k_abs*Q_gut/BW k_empt = k_min+(k_max-k_min)/2*(tanh(aa*(Q_sto-b*D))-tanh(cc*(Q_sto-d*D))+2) -U_idm = part_m*V_mmax*G_t/(K_m0+G_t) -U_idf = part_f*nC*(k8*GLUT4m*G_t/pf + glut1*G_t/pf + kbf*(INS+5)*1e-3) +U_idm = 0.5*V_mmax*G_t/(K_m0+G_t) +U_idf = 0.5*scaleModel*(k8*GLUT4m*G_t/34 + glut1*G_t/34 + kbf*(INS+5)*1e-3) +U = U_ii+U_id S_po = Y+K*(EGP+Ra-E-U_ii-k_1*G_p+k_2*G_t)/V_G+S_b -U_idl = part_l*U_idm -U_id = U_idm+U_idf+U_idl +U_liver = 45*U_idm/27 +U_ii = 23*U_liver/45 +U_id = U_idm+U_idf+U_liver ********** MODEL REACTIONS v1a = IR*k1a*(INS+5)*1e-3 @@ -259,4 +254,4 @@ glucoseuptake = k8*GLUT4m*(G_t*5/170) + glut1*(G_t*5/170) + kbf*((INS+5)*1e-3) ********** MODEL EVENTS event1 = gt(G_p,339),E,Ee event2 = lt(G_p,339),E,0 -********** MODEL MATLAB FUNCTIONS \ No newline at end of file +********** MODEL MATLAB FUNCTIONS