From 14196bba2cbf062f86395ef893383af15bcc9a31 Mon Sep 17 00:00:00 2001
From: herrTilda <tilda.herrgardh@gmail.com>
Date: Sat, 23 Jan 2021 13:33:48 +0100
Subject: [PATCH] SBML models
---
scripts/Models/M1.txt | 6 +-
scripts/Models/M1.xml | 2585 ++++++++++++++++++++++++++++++++++++++++
scripts/Models/M4m.xml | 438 +++++++
3 files changed, 3026 insertions(+), 3 deletions(-)
create mode 100644 scripts/Models/M1.xml
create mode 100644 scripts/Models/M4m.xml
diff --git a/scripts/Models/M1.txt b/scripts/Models/M1.txt
index ada9d80..84cf631 100644
--- a/scripts/Models/M1.txt
+++ b/scripts/Models/M1.txt
@@ -31,7 +31,8 @@ d/dt(GLUT4) = -v7f+v7b %%24
d/dt(S6K) = v9b1-v9f1 %%26
d/dt(S6Kp) = v9f1-v9b1 %%27
d/dt(S6) = v9b2-v9f2 %%28
-d/dt(S6p) = v9f2-v9b2 %%29
+d/dt(S6p) = v9f2-v9b2 %%29
+
d/dt(G_p) = EGP+Ra-E-U_ii-k_1*G_p+k_2*G_t
d/dt(G_t) = (-U_id)+k_1*G_p-k_2*G_t
d/dt(I_p) = (-m_2*I_p)-m_4*I_p+m_1*I_l
@@ -196,8 +197,7 @@ aa = 5/2/(1-b)/D
cc = 5/2/d/D
EGP = k_p1-k_p2*G_p-k_p3*I_d-k_p4*I_po
V_mmax = (1-part)*(V_m0+V_mX*INS)
-V_fmax = part*(V_f0+V_fX*INS)
-V_lmax = (1-part)*(V_l0+V_lX*INS)
+V_fmax = part*(V_f0+V_fX*INS)
Ee = k_e1*(G_p - k_e2)
S = gamma*I_po
I = I_p/V_I
diff --git a/scripts/Models/M1.xml b/scripts/Models/M1.xml
new file mode 100644
index 0000000..b7e1f97
--- /dev/null
+++ b/scripts/Models/M1.xml
@@ -0,0 +1,2585 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<sbml xmlns="http://www.sbml.org/sbml/level2" level="2" version="1">
+ <model name="M1_SBML">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+ <p>adipocyte = 1 {isCompartment:}</p>
+ <p>liver = 1 {isCompartment:}</p>
+ <p>tissue = 1 {isCompartment:}</p>
+ <p>muscle = 1 {isCompartment:}</p>
+ <p>plasma = 1 {isCompartment:}</p>
+ <p>fat = 1 {isCompartment:}</p>
+ <p>stomach = 1 {isCompartment:}</p>
+ <p>intestine = 1 {isCompartment:}</p>
+ <p>betaCell = 1 {isCompartment:}</p>
+ <p>kidney = 1 {isCompartment:}</p>
+ </body>
+ </html>
+ </notes>
+ <listOfCompartments>
+ <compartment id="rootCompartment" name="rootCompartment" spatialDimensions="3" size="1" constant="true"/>
+ </listOfCompartments>
+ <listOfSpecies>
+ <species id="IR" name="IR" compartment="adipocyte" initialConcentration="100" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%1</body>
+ </html>
+ </notes>
+ </species>
+ <species id="IRp" name="IRp" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%2</body>
+ </html>
+ </notes>
+ </species>
+ <species id="IRins" name="IRins" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%3</body>
+ </html>
+ </notes>
+ </species>
+ <species id="IRip" name="IRip" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%4</body>
+ </html>
+ </notes>
+ </species>
+ <species id="IRi" name="IRi" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%5</body>
+ </html>
+ </notes>
+ </species>
+ <species id="IRS1" name="IRS1" compartment="adipocyte" initialConcentration="100" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%6</body>
+ </html>
+ </notes>
+ </species>
+ <species id="IRS1p" name="IRS1p" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%7</body>
+ </html>
+ </notes>
+ </species>
+ <species id="IRS1p307" name="IRS1p307" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%8</body>
+ </html>
+ </notes>
+ </species>
+ <species id="IRS1307" name="IRS1307" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%9</body>
+ </html>
+ </notes>
+ </species>
+ <species id="X" name="X" compartment="adipocyte" initialConcentration="100" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%10</body>
+ </html>
+ </notes>
+ </species>
+ <species id="Xp" name="Xp" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%12</body>
+ </html>
+ </notes>
+ </species>
+ <species id="PKB" name="PKB" compartment="adipocyte" initialConcentration="100" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%13</body>
+ </html>
+ </notes>
+ </species>
+ <species id="PKB308p" name="PKB308p" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%14</body>
+ </html>
+ </notes>
+ </species>
+ <species id="PKB473p" name="PKB473p" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%15</body>
+ </html>
+ </notes>
+ </species>
+ <species id="PKB308p473p" name="PKB308p473p" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%16</body>
+ </html>
+ </notes>
+ </species>
+ <species id="mTORC1" name="mTORC1" compartment="adipocyte" initialConcentration="100" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%17</body>
+ </html>
+ </notes>
+ </species>
+ <species id="mTORC1a" name="mTORC1a" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%18</body>
+ </html>
+ </notes>
+ </species>
+ <species id="mTORC2" name="mTORC2" compartment="adipocyte" initialConcentration="100" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%19</body>
+ </html>
+ </notes>
+ </species>
+ <species id="mTORC2a" name="mTORC2a" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%20</body>
+ </html>
+ </notes>
+ </species>
+ <species id="AS160" name="AS160" compartment="adipocyte" initialConcentration="100" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%21</body>
+ </html>
+ </notes>
+ </species>
+ <species id="AS160p" name="AS160p" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%22</body>
+ </html>
+ </notes>
+ </species>
+ <species id="GLUT4m" name="GLUT4m" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%23</body>
+ </html>
+ </notes>
+ </species>
+ <species id="GLUT4" name="GLUT4" compartment="adipocyte" initialConcentration="100" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%24</body>
+ </html>
+ </notes>
+ </species>
+ <species id="S6K" name="S6K" compartment="adipocyte" initialConcentration="100" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%26</body>
+ </html>
+ </notes>
+ </species>
+ <species id="S6Kp" name="S6Kp" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%27</body>
+ </html>
+ </notes>
+ </species>
+ <species id="S6" name="S6" compartment="adipocyte" initialConcentration="100" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%28</body>
+ </html>
+ </notes>
+ </species>
+ <species id="S6p" name="S6p" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%29</body>
+ </html>
+ </notes>
+ </species>
+ <species id="G_p" name="G_p" compartment="plasma" initialAmount="178" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="G_t" name="G_t" compartment="tissue" initialAmount="130" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="I_l" name="I_l" compartment="liver" initialAmount="4.5" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="I_p" name="I_p" compartment="plasma" initialAmount="1.25" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="Q_sto1" name="Q_sto1" compartment="stomach" initialAmount="78000" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="Q_sto2" name="Q_sto2" compartment="stomach" initialAmount="0" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="Q_gut" name="Q_gut" compartment="intenstine" initialAmount="0" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="I_1" name="I_1" compartment="liver" initialAmount="25" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="I_d" name="I_d" compartment="liver" initialAmount="25" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="INS" name="INS" compartment="tissue" initialAmount="0" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="I_po" name="I_po" compartment="liver" initialAmount="3.6" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="Y" name="Y" compartment="betaCell" initialAmount="0" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="I" name="I" compartment="plasma" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ <species id="G" name="G" compartment="plasma" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ <species id="Q_sto" name="Q_sto" compartment="stomach" initialAmount="0" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="U_idm" name="U_idm" compartment="muscle" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ <species id="U_idf" name="U_idf" compartment="fat" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ <species id="S_po" name="S_po" compartment="liver" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ <species id="U_idl" name="U_idl" compartment="liver" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ <species id="U_id" name="U_id" compartment="tissue" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ <species id="glucoseuptake" name="glucoseuptake" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ </listOfSpecies>
+ <listOfParameters>
+ <parameter id="diabetes" name="diabetes" value="1" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%1</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k1a" name="k1a" value="0.633141" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%2</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k1basal" name="k1basal" value="0.0331338" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%3</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k1c" name="k1c" value="0.876805" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%4</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k1d" name="k1d" value="31.012" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%5</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k1f" name="k1f" value="1839.58" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%6</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k1g" name="k1g" value="1944.11" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%7</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k1r" name="k1r" value="0.547061" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%8</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k2a" name="k2a" value="3.22728" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%9</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k2c" name="k2c" value="5758.78" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%10</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k2basal" name="k2basal" value="0.0422768" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%11</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k2b" name="k2b" value="3424.35" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%12</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k2d" name="k2d" value="280.753" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%13</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k2f" name="k2f" value="2.9131" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%14</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k2g" name="k2g" value="0.267089" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%15</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k3a" name="k3a" value="0.00137731" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%16</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k3b" name="k3b" value="0.0987558" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%17</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k4a" name="k4a" value="5790.17" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%18</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k4b" name="k4b" value="34.7965" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%19</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k4c" name="k4c" value="4.45581" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%20</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k4e" name="k4e" value="42.8395" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%21</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k4f" name="k4f" value="143.597" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%22</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k4h" name="k4h" value="0.536145" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%23</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k5a1" name="k5a1" value="1.8423" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%24</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k5a2" name="k5a2" value="0.055064" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%25</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k5b" name="k5b" value="24.826" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%26</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k5d" name="k5d" value="1.06013" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%27</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="km5" name="km5" value="2.64988" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%28</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k5c" name="k5c" value="0.0857515" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%29</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k6f1" name="k6f1" value="2.65168" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%30</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k6f2" name="k6f2" value="36.9348" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%31</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="km6" name="km6" value="30.5424" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%32</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="n6" name="n6" value="2.13707" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%33</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k6b" name="k6b" value="65.1841" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%34</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k7f" name="k7f" value="50.9829" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%35</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k7b" name="k7b" value="2285.97" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%36</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k8" name="k8" value="724.242" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%37</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="glut1" name="glut1" value="7042.19" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%38</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k9f1" name="k9f1" value="0.12981" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%39</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k9b1" name="k9b1" value="0.0444092" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%40</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k9f2" name="k9f2" value="3.3289" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%41</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k9b2" name="k9b2" value="30.9967" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%42</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="km9" name="km9" value="5872.68" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%43</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="n9" name="n9" value="0.985466" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%44</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="kbf" name="kbf" value="1000000" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%45</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="nC" name="nC" value="2.1e-006" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%46</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="V_G" name="V_G" value="1.88" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 47</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_1" name="k_1" value="0.065" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 48</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_2" name="k_2" value="0.079" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 49</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="G_b" name="G_b" value="95" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 50</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="V_I" name="V_I" value="0.05" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 51</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="m_1" name="m_1" value="0.19" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 52</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="m_2" name="m_2" value="0.484" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 53</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="m_4" name="m_4" value="0.194" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 54</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="m_5" name="m_5" value="0.0304" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 55</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="m_6" name="m_6" value="0.6471" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 56</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="HE_b" name="HE_b" value="0.6" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 57</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="I_b" name="I_b" value="25" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 58</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="S_b" name="S_b" value="1.8" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 59</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_max" name="k_max" value="0.0558" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 60</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_min" name="k_min" value="0.008" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 61</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_abs" name="k_abs" value="0.057" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 62</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_gri" name="k_gri" value="0.0558" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 63</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="f" name="f" value="0.9" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 64</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="b" name="b" value="0.82" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 65</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="d" name="d" value="0.01" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 66</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="BW" name="BW" value="78" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 67</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_p1" name="k_p1" value="2.7" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 68</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_p2" name="k_p2" value="0.0021" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 69</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_p3" name="k_p3" value="0.009" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 70</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_p4" name="k_p4" value="0.0618" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 71</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_i" name="k_i" value="0.0079" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+% 72</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="V_m0" name="V_m0" value="2.5" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%73</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="V_mX" name="V_mX" value="0.047" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%74</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="K_m0" name="K_m0" value="225.59" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%75</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="V_f0" name="V_f0" value="2.5" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%76</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="V_fX" name="V_fX" value="0.047" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%77</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="K_f0" name="K_f0" value="225.59" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%78</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="p_2U" name="p_2U" value="0.0331" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%79</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="part" name="part" value="0.2" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%80</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="K" name="K" value="2.3" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%81</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="alpha" name="alpha" value="0.05" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%82</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="beta" name="beta" value="0.11" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%83</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="gamma" name="gamma" value="0.5" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%84</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_e1" name="k_e1" value="0" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%85</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="k_e2" name="k_e2" value="339" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%86</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="D" name="D" value="78000" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%87</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="K_l0" name="K_l0" value="225.59" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%88</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="V_l0" name="V_l0" value="2.5" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%89</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="V_lX" name="V_lX" value="0.047" constant="true">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%90</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="pf" name="pf" value="34" constant="true"/>
+ <parameter id="U_ii" name="U_ii" value="0.8" constant="true"/>
+ <parameter id="part_m" name="part_m" value="0.5" constant="true"/>
+ <parameter id="part_f" name="part_f" value="0.5" constant="true"/>
+ <parameter id="part_l" name="part_l" value="1.7" constant="true"/>
+ <parameter id="aa" name="aa" value="0" constant="false"/>
+ <parameter id="cc" name="cc" value="0" constant="false"/>
+ <parameter id="EGP" name="EGP" value="0" constant="false"/>
+ <parameter id="V_mmax" name="V_mmax" value="0" constant="false"/>
+ <parameter id="V_fmax" name="V_fmax" value="0" constant="false"/>
+ <parameter id="E" name="E" value="0" constant="false"/>
+ <parameter id="S" name="S" value="0" constant="false"/>
+ <parameter id="HE" name="HE" value="0" constant="false"/>
+ <parameter id="m_3" name="m_3" value="0" constant="false"/>
+ <parameter id="Ra" name="Ra" value="0" constant="false"/>
+ <parameter id="k_empt" name="k_empt" value="0" constant="false"/>
+ <parameter id="v1a" name="v1a" value="0" constant="false"/>
+ <parameter id="v1basal" name="v1basal" value="0" constant="false"/>
+ <parameter id="v1c" name="v1c" value="0" constant="false"/>
+ <parameter id="v1d" name="v1d" value="0" constant="false"/>
+ <parameter id="v1e" name="v1e" value="0" constant="false"/>
+ <parameter id="v1g" name="v1g" value="0" constant="false"/>
+ <parameter id="v1r" name="v1r" value="0" constant="false"/>
+ <parameter id="v2a" name="v2a" value="0" constant="false"/>
+ <parameter id="v2b" name="v2b" value="0" constant="false"/>
+ <parameter id="v2c" name="v2c" value="0" constant="false"/>
+ <parameter id="v2d" name="v2d" value="0" constant="false"/>
+ <parameter id="v2f" name="v2f" value="0" constant="false"/>
+ <parameter id="v2basal" name="v2basal" value="0" constant="false"/>
+ <parameter id="v2g" name="v2g" value="0" constant="false"/>
+ <parameter id="v3a" name="v3a" value="0" constant="false"/>
+ <parameter id="v3b" name="v3b" value="0" constant="false"/>
+ <parameter id="v5a" name="v5a" value="0" constant="false"/>
+ <parameter id="v5b" name="v5b" value="0" constant="false"/>
+ <parameter id="v5c" name="v5c" value="0" constant="false"/>
+ <parameter id="v5d" name="v5d" value="0" constant="false"/>
+ <parameter id="v4a" name="v4a" value="0" constant="false"/>
+ <parameter id="v4b" name="v4b" value="0" constant="false"/>
+ <parameter id="v4c" name="v4c" value="0" constant="false"/>
+ <parameter id="v4e" name="v4e" value="0" constant="false"/>
+ <parameter id="v4f" name="v4f" value="0" constant="false"/>
+ <parameter id="v4h" name="v4h" value="0" constant="false"/>
+ <parameter id="v6f1" name="v6f1" value="0" constant="false"/>
+ <parameter id="v6b1" name="v6b1" value="0" constant="false"/>
+ <parameter id="v7f" name="v7f" value="0" constant="false"/>
+ <parameter id="v7b" name="v7b" value="0" constant="false"/>
+ <parameter id="v9f1" name="v9f1" value="0" constant="false"/>
+ <parameter id="v9b1" name="v9b1" value="0" constant="false"/>
+ <parameter id="v9f2" name="v9f2" value="0" constant="false"/>
+ <parameter id="v9b2" name="v9b2" value="0" constant="false"/>
+ </listOfParameters>
+ <listOfRules>
+ <rateRule variable="IR">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%1</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <plus/>
+ <apply>
+ <minus/>
+ <apply>
+ <minus/>
+ <ci> v1a </ci>
+ </apply>
+ <ci> v1basal </ci>
+ </apply>
+ <ci> v1r </ci>
+ <ci> v1g </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="IRp">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%2</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <apply>
+ <minus/>
+ <apply>
+ <plus/>
+ <ci> v1basal </ci>
+ <ci> v1c </ci>
+ </apply>
+ <ci> v1d </ci>
+ </apply>
+ <ci> v1g </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="IRins">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%3</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <ci> v1a </ci>
+ <ci> v1c </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="IRip">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%4</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <ci> v1d </ci>
+ <ci> v1e </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="IRi">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%5</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <ci> v1e </ci>
+ <ci> v1r </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="IRS1">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%6</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <apply>
+ <minus/>
+ <apply>
+ <plus/>
+ <ci> v2b </ci>
+ <ci> v2g </ci>
+ </apply>
+ <ci> v2a </ci>
+ </apply>
+ <ci> v2basal </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="IRS1p">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%7</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <apply>
+ <minus/>
+ <apply>
+ <plus/>
+ <ci> v2a </ci>
+ <ci> v2d </ci>
+ </apply>
+ <ci> v2b </ci>
+ </apply>
+ <ci> v2c </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="IRS1p307">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%8</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <apply>
+ <minus/>
+ <ci> v2c </ci>
+ <ci> v2d </ci>
+ </apply>
+ <ci> v2f </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="IRS1307">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%9</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <apply>
+ <plus/>
+ <ci> v2basal </ci>
+ <ci> v2f </ci>
+ </apply>
+ <ci> v2g </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="X">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%10</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <ci> v3b </ci>
+ <ci> v3a </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="Xp">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%12</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <ci> v3a </ci>
+ <ci> v3b </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="PKB">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%13</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <plus/>
+ <apply>
+ <minus/>
+ <ci> v4a </ci>
+ </apply>
+ <ci> v4b </ci>
+ <ci> v4h </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="PKB308p">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%14</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <apply>
+ <minus/>
+ <ci> v4a </ci>
+ <ci> v4b </ci>
+ </apply>
+ <ci> v4c </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="PKB473p">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+%15</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <apply>
+ <plus/>
+ <apply>
+ <minus/>
+ <ci> v4e </ci>
+ </apply>
+ <ci> v4f </ci>
+ </apply>
+ <ci> v4h </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="PKB308p473p">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
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+ <ci> k2a </ci>
+ <ci> IRip </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v2b">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> IRS1p </ci>
+ <ci> k2b </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v2c">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> IRS1p </ci>
+ <ci> k2c </ci>
+ <ci> mTORC1a </ci>
+ <ci> diabetes </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v2d">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> IRS1p307 </ci>
+ <ci> k2d </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v2f">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> IRS1p307 </ci>
+ <ci> k2f </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v2basal">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> IRS1 </ci>
+ <ci> k2basal </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v2g">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> IRS1307 </ci>
+ <ci> k2g </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v3a">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> X </ci>
+ <ci> k3a </ci>
+ <ci> IRS1p </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v3b">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> Xp </ci>
+ <ci> k3b </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v5a">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> mTORC1 </ci>
+ <apply>
+ <plus/>
+ <apply>
+ <times/>
+ <ci> k5a1 </ci>
+ <ci> PKB308p473p </ci>
+ </apply>
+ <apply>
+ <times/>
+ <ci> k5a2 </ci>
+ <ci> PKB308p </ci>
+ </apply>
+ </apply>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v5b">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> mTORC1a </ci>
+ <ci> k5b </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v5c">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> mTORC2 </ci>
+ <ci> k5c </ci>
+ <ci> IRip </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v5d">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> k5d </ci>
+ <ci> mTORC2a </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v4a">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> k4a </ci>
+ <ci> PKB </ci>
+ <ci> IRS1p </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v4b">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> k4b </ci>
+ <ci> PKB308p </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v4c">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> k4c </ci>
+ <ci> PKB308p </ci>
+ <ci> mTORC2a </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v4e">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> k4e </ci>
+ <ci> PKB473p </ci>
+ <ci> IRS1p307 </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v4f">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> k4f </ci>
+ <ci> PKB308p473p </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v4h">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> k4h </ci>
+ <ci> PKB473p </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v6f1">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> AS160 </ci>
+ <apply>
+ <plus/>
+ <apply>
+ <times/>
+ <ci> k6f1 </ci>
+ <ci> PKB308p473p </ci>
+ </apply>
+ <apply>
+ <divide/>
+ <apply>
+ <times/>
+ <ci> k6f2 </ci>
+ <apply>
+ <power/>
+ <ci> PKB473p </ci>
+ <ci> n6 </ci>
+ </apply>
+ </apply>
+ <apply>
+ <plus/>
+ <apply>
+ <power/>
+ <ci> km6 </ci>
+ <ci> n6 </ci>
+ </apply>
+ <apply>
+ <power/>
+ <ci> PKB473p </ci>
+ <ci> n6 </ci>
+ </apply>
+ </apply>
+ </apply>
+ </apply>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v6b1">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> AS160p </ci>
+ <ci> k6b </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v7f">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> GLUT4 </ci>
+ <ci> k7f </ci>
+ <ci> AS160p </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v7b">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> GLUT4m </ci>
+ <ci> k7b </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v9f1">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <divide/>
+ <apply>
+ <times/>
+ <ci> S6K </ci>
+ <ci> k9f1 </ci>
+ <apply>
+ <power/>
+ <ci> mTORC1a </ci>
+ <ci> n9 </ci>
+ </apply>
+ </apply>
+ <apply>
+ <plus/>
+ <apply>
+ <power/>
+ <ci> km9 </ci>
+ <ci> n9 </ci>
+ </apply>
+ <apply>
+ <power/>
+ <ci> mTORC1a </ci>
+ <ci> n9 </ci>
+ </apply>
+ </apply>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v9b1">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> S6Kp </ci>
+ <ci> k9b1 </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v9f2">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> S6 </ci>
+ <ci> k9f2 </ci>
+ <ci> S6Kp </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="v9b2">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> S6p </ci>
+ <ci> k9b2 </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="glucoseuptake">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <plus/>
+ <apply>
+ <times/>
+ <ci> k8 </ci>
+ <ci> GLUT4m </ci>
+ <apply>
+ <divide/>
+ <apply>
+ <times/>
+ <ci> G_t </ci>
+ <cn type="integer"> 5 </cn>
+ </apply>
+ <cn type="integer"> 170 </cn>
+ </apply>
+ </apply>
+ <apply>
+ <times/>
+ <ci> glut1 </ci>
+ <apply>
+ <divide/>
+ <apply>
+ <times/>
+ <ci> G_t </ci>
+ <cn type="integer"> 5 </cn>
+ </apply>
+ <cn type="integer"> 170 </cn>
+ </apply>
+ </apply>
+ <apply>
+ <times/>
+ <ci> kbf </ci>
+ <apply>
+ <plus/>
+ <ci> INS </ci>
+ <cn type="integer"> 5 </cn>
+ </apply>
+ <cn type="e-notation"> 1 <sep/> -3 </cn>
+ </apply>
+ </apply>
+ </math>
+ </assignmentRule>
+ </listOfRules>
+ </model>
+</sbml>
diff --git a/scripts/Models/M4m.xml b/scripts/Models/M4m.xml
new file mode 100644
index 0000000..fb22ef5
--- /dev/null
+++ b/scripts/Models/M4m.xml
@@ -0,0 +1,438 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<sbml xmlns="http://www.sbml.org/sbml/level2" level="2" version="1">
+ <model name="M4m_SBML">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+ <p>sub-model version of M4, with EGP, Ra, GLUT4m, and INS as input curves
+</p>
+ <p>adipocyte = 1 {isCompartment:}
+</p>
+ <p>liver = 1 {isCompartment:}
+</p>
+ <p>tissue = 1 {isCompartment:}
+</p>
+ <p>muscle = 1 {isCompartment:}
+</p>
+ <p>plasma = 1 {isCompartment:}
+</p>
+ <p>fat = 1 {isCompartment:}</p>
+ </body>
+ </html>
+ </notes>
+ <listOfCompartments>
+ <compartment id="rootCompartment" name="rootCompartment" spatialDimensions="3" size="1" constant="true"/>
+ </listOfCompartments>
+ <listOfSpecies>
+ <species id="G_p" name="G_p" compartment="tissue" initialAmount="178" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="G_t" name="G_t" compartment="tissue" initialAmount="130" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="Glu_in" name="Glu_in" compartment="adipocyte" initialAmount="0" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="G6P" name="G6P" compartment="adipocyte" initialAmount="0" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="INS" name="INS" compartment="tissue" initialAmount="0" hasOnlySubstanceUnits="true" boundaryCondition="true" constant="false"/>
+ <species id="GLUT4m" name="GLUT4m" compartment="adipocyte" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ <species id="U_idm" name="U_idm" compartment="muscle" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ <species id="U_idl" name="U_idl" compartment="liver" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ <species id="U_idf" name="U_idf" compartment="fat" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ <species id="U_id" name="U_id" compartment="tissue" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ <species id="G" name="G" compartment="plasma" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
+ </listOfSpecies>
+ <listOfParameters>
+ <parameter id="bradykinin" name="bradykinin" value="1" constant="true"/>
+ <parameter id="kbf" name="kbf" value="0.01" constant="true"/>
+ <parameter id="INS_offset" name="INS_offset" value="7" constant="true"/>
+ <parameter id="be" name="be" value="3" constant="true"/>
+ <parameter id="nC" name="nC" value="2.1e-006" constant="true"/>
+ <parameter id="k8" name="k8" value="724.242" constant="true"/>
+ <parameter id="glut1" name="glut1" value="7042.19" constant="true"/>
+ <parameter id="k_1" name="k_1" value="0.065" constant="true"/>
+ <parameter id="k_2" name="k_2" value="0.079" constant="true"/>
+ <parameter id="pf" name="pf" value="34" constant="true"/>
+ <parameter id="V_m" name="V_m" value="2553.38" constant="true"/>
+ <parameter id="V_mx" name="V_mx" value="2.63167" constant="true"/>
+ <parameter id="K_m" name="K_m" value="129.391" constant="true"/>
+ <parameter id="part_l" name="part_l" value="0.00249792" constant="true"/>
+ <parameter id="K_l" name="K_l" value="0.120151" constant="true"/>
+ <parameter id="p1" name="p1" value="427.534" constant="true"/>
+ <parameter id="p2" name="p2" value="423.661" constant="true"/>
+ <parameter id="p3" name="p3" value="7e-005" constant="true"/>
+ <parameter id="p4" name="p4" value="4389.24" constant="true"/>
+ <parameter id="part_f" name="part_f" value="0.932088" constant="true"/>
+ <parameter id="k_gluin" name="k_gluin" value="0.159629" constant="true"/>
+ <parameter id="k_G6P" name="k_G6P" value="0.0015" constant="true"/>
+ <parameter id="V_G6Pmax" name="V_G6Pmax" value="11.549" constant="true"/>
+ <parameter id="U_ii" name="U_ii" value="1.02548" constant="true"/>
+ <parameter id="EGP1" name="EGP1" value="1" constant="true"/>
+ <parameter id="EGP2" name="EGP2" value="1" constant="true"/>
+ <parameter id="EGP3" name="EGP3" value="1" constant="true"/>
+ <parameter id="EGP4" name="EGP4" value="1" constant="true"/>
+ <parameter id="EGP5" name="EGP5" value="1" constant="true"/>
+ <parameter id="EGP6" name="EGP6" value="1" constant="true"/>
+ <parameter id="EGP7" name="EGP7" value="1" constant="true"/>
+ <parameter id="EGP8" name="EGP8" value="1" constant="true"/>
+ <parameter id="EGP9" name="EGP9" value="1" constant="true"/>
+ <parameter id="Ra1" name="Ra1" value="1" constant="true"/>
+ <parameter id="Ra2" name="Ra2" value="1" constant="true"/>
+ <parameter id="Ra3" name="Ra3" value="1" constant="true"/>
+ <parameter id="Ra4" name="Ra4" value="1" constant="true"/>
+ <parameter id="Ra5" name="Ra5" value="1" constant="true"/>
+ <parameter id="Ra6" name="Ra6" value="1" constant="true"/>
+ <parameter id="Ra7" name="Ra7" value="1" constant="true"/>
+ <parameter id="Ra8" name="Ra8" value="1" constant="true"/>
+ <parameter id="Ra9" name="Ra9" value="1" constant="true"/>
+ <parameter id="INS1" name="INS1" value="1" constant="true"/>
+ <parameter id="INS2" name="INS2" value="1" constant="true"/>
+ <parameter id="INS3" name="INS3" value="1" constant="true"/>
+ <parameter id="INS4" name="INS4" value="1" constant="true"/>
+ <parameter id="INS5" name="INS5" value="1" constant="true"/>
+ <parameter id="INS6" name="INS6" value="1" constant="true"/>
+ <parameter id="INS7" name="INS7" value="1" constant="true"/>
+ <parameter id="INS8" name="INS8" value="1" constant="true"/>
+ <parameter id="INS9" name="INS9" value="1" constant="true"/>
+ <parameter id="GLm1" name="GLm1" value="1" constant="true"/>
+ <parameter id="GLm2" name="GLm2" value="1" constant="true"/>
+ <parameter id="GLm3" name="GLm3" value="1" constant="true"/>
+ <parameter id="GLm4" name="GLm4" value="1" constant="true"/>
+ <parameter id="GLm5" name="GLm5" value="1" constant="true"/>
+ <parameter id="GLm6" name="GLm6" value="1" constant="true"/>
+ <parameter id="GLm7" name="GLm7" value="1" constant="true"/>
+ <parameter id="GLm8" name="GLm8" value="1" constant="true"/>
+ <parameter id="GLm9" name="GLm9" value="1" constant="true"/>
+ <parameter id="EGP" name="EGP" value="0" constant="false"/>
+ <parameter id="Ra" name="Ra" value="0" constant="false"/>
+ <parameter id="E" name="E" value="0" constant="false"/>
+ <parameter id="bf_f" name="bf_f" value="0" constant="false"/>
+ <parameter id="bfe_f" name="bfe_f" value="0" constant="false"/>
+ <parameter id="part_m" name="part_m" value="0" constant="false"/>
+ <parameter id="V_mmax" name="V_mmax" value="0" constant="false"/>
+ <parameter id="V_lmax" name="V_lmax" value="0" constant="false">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+(V_l+V_lx*INS)</body>
+ </html>
+ </notes>
+ </parameter>
+ <parameter id="INS_fe" name="INS_fe" value="0" constant="false"/>
+ <parameter id="V_in" name="V_in" value="0" constant="false"/>
+ <parameter id="V_out" name="V_out" value="0" constant="false"/>
+ <parameter id="V_G" name="V_G" value="0" constant="false"/>
+ <parameter id="V_G6P" name="V_G6P" value="0" constant="false"/>
+ <parameter id="V_met" name="V_met" value="0" constant="false"/>
+ </listOfParameters>
+ <listOfRules>
+ <rateRule variable="G_p">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <plus/>
+ <apply>
+ <minus/>
+ <apply>
+ <minus/>
+ <apply>
+ <minus/>
+ <apply>
+ <plus/>
+ <ci> EGP </ci>
+ <ci> Ra </ci>
+ </apply>
+ <ci> E </ci>
+ </apply>
+ <ci> U_ii </ci>
+ </apply>
+ <apply>
+ <times/>
+ <ci> k_1 </ci>
+ <ci> G_p </ci>
+ </apply>
+ </apply>
+ <apply>
+ <times/>
+ <ci> k_2 </ci>
+ <ci> G_t </ci>
+ </apply>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="G_t">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <apply>
+ <plus/>
+ <apply>
+ <minus/>
+ <ci> U_id </ci>
+ </apply>
+ <apply>
+ <times/>
+ <ci> k_1 </ci>
+ <ci> G_p </ci>
+ </apply>
+ </apply>
+ <apply>
+ <times/>
+ <ci> k_2 </ci>
+ <ci> G_t </ci>
+ </apply>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="Glu_in">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <apply>
+ <times/>
+ <ci> p1 </ci>
+ <apply>
+ <minus/>
+ <ci> V_in </ci>
+ <ci> V_out </ci>
+ </apply>
+ </apply>
+ <ci> V_G6P </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <rateRule variable="G6P">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <ci> V_G6P </ci>
+ <ci> V_met </ci>
+ </apply>
+ </math>
+ </rateRule>
+ <assignmentRule variable="INS"/>
+ <assignmentRule variable="EGP"/>
+ <assignmentRule variable="Ra"/>
+ <assignmentRule variable="GLUT4m"/>
+ <assignmentRule variable="E">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <cn type="integer"> 0 </cn>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="bf_f">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> bradykinin </ci>
+ <apply>
+ <plus/>
+ <ci> be </ci>
+ <apply>
+ <times/>
+ <ci> kbf </ci>
+ <apply>
+ <plus/>
+ <ci> INS </ci>
+ <ci> INS_offset </ci>
+ </apply>
+ </apply>
+ </apply>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="bfe_f">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <ci> bf_f </ci>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="part_m">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <minus/>
+ <cn type="integer"> 1 </cn>
+ <ci> part_l </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="V_mmax">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> part_m </ci>
+ <apply>
+ <plus/>
+ <ci> V_m </ci>
+ <apply>
+ <times/>
+ <ci> V_mx </ci>
+ <ci> INS </ci>
+ </apply>
+ </apply>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="V_lmax">
+ <notes>
+ <html xmlns="http://www.w3.org/1999/xhtml">
+ <body>
+(V_l+V_lx*INS)</body>
+ </html>
+ </notes>
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> part_l </ci>
+ <ci> V_mmax </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="INS_fe">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> nC </ci>
+ <apply>
+ <plus/>
+ <apply>
+ <divide/>
+ <apply>
+ <times/>
+ <ci> k8 </ci>
+ <ci> GLUT4m </ci>
+ </apply>
+ <ci> pf </ci>
+ </apply>
+ <apply>
+ <divide/>
+ <ci> glut1 </ci>
+ <ci> pf </ci>
+ </apply>
+ <ci> bfe_f </ci>
+ </apply>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="V_in">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> p4 </ci>
+ <ci> G_t </ci>
+ <ci> INS_fe </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="V_out">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> p3 </ci>
+ <ci> Glu_in </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="U_idm">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <divide/>
+ <apply>
+ <times/>
+ <ci> V_mmax </ci>
+ <ci> G_t </ci>
+ </apply>
+ <apply>
+ <plus/>
+ <ci> K_m </ci>
+ <ci> G_t </ci>
+ </apply>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="U_idl">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <divide/>
+ <apply>
+ <times/>
+ <ci> V_lmax </ci>
+ <ci> G_t </ci>
+ </apply>
+ <apply>
+ <plus/>
+ <ci> K_l </ci>
+ <ci> G_t </ci>
+ </apply>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="U_idf">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> part_f </ci>
+ <apply>
+ <minus/>
+ <ci> V_in </ci>
+ <ci> V_out </ci>
+ </apply>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="U_id">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <plus/>
+ <ci> U_idf </ci>
+ <ci> U_idm </ci>
+ <ci> U_idl </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="V_G">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <cn> 1.88 </cn>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="G">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <divide/>
+ <ci> G_p </ci>
+ <ci> V_G </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="V_G6P">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <divide/>
+ <apply>
+ <times/>
+ <apply>
+ <divide/>
+ <apply>
+ <times/>
+ <ci> V_G6Pmax </ci>
+ <ci> Glu_in </ci>
+ </apply>
+ <apply>
+ <plus/>
+ <ci> k_gluin </ci>
+ <ci> Glu_in </ci>
+ </apply>
+ </apply>
+ <cn type="integer"> 1 </cn>
+ </apply>
+ <apply>
+ <plus/>
+ <ci> k_G6P </ci>
+ <ci> G6P </ci>
+ </apply>
+ </apply>
+ </math>
+ </assignmentRule>
+ <assignmentRule variable="V_met">
+ <math xmlns="http://www.w3.org/1998/Math/MathML">
+ <apply>
+ <times/>
+ <ci> p2 </ci>
+ <ci> G6P </ci>
+ </apply>
+ </math>
+ </assignmentRule>
+ </listOfRules>
+ </model>
+</sbml>
--
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